[Experimental and clinical studies on the deodorant, Flagyl (Metronidazole)].

Animal experiment: Subctaneous injection of suspension of odoriferous pus collected from the lesion of experimental Vincent's disease induced on a guinea pig was made in depilated back of another guinea pig weighing from 250 to 350 grams. The water solutions of Flagyl were injected subctaneously to the other portion on the back of the guinea pig, 10, 5 and 2.5mgs a day for 7 days respectively. The Flagyl group had a less production of pus and did not remain spirochaete or odour in the pus. Clinical trial: Clinical examination was made in 50 adults who were pointed out halitosis by means of double blind method. They were given 400mgs of either Flagyl or placebo tablets once a day for 5 days. Unexpectancy, disappearance of halitosis was not experienced only in the Flagyl group. The consideration of these results was discussed.